MersV1, Main, Exploration, bibRecord, 001E46

Middle East Respiratory Syndrome Coronavirus: A Case-Control Study of Hospitalized Patients

Identifieur interne : 001E46 ( Main/Exploration ); précédent : 001E45; suivant : 001E47

Middle East Respiratory Syndrome Coronavirus: A Case-Control Study of Hospitalized Patients

Auteurs : Jaffar A. Al-Tawfiq [Arabie saoudite, États-Unis] ; Kareem Hinedi [Arabie saoudite] ; Jihad Ghandour [Arabie saoudite] ; Hanan Khairalla [Arabie saoudite] ; Samir Musleh [Arabie saoudite] ; Alaa Ujayli [Arabie saoudite] ; Ziad A. Memish [Arabie saoudite]

Source :

Clinical infectious diseases [ 1058-4838 ] ; 2014.

RBID : Pascal:14-0183590

Descripteurs français

KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Coronavirus du syndrome respiratoire du Moyen-Orient (isolement et purification), Diagnostic différentiel, Enfant, Enfant d'âge préscolaire, Femelle, Humains, Infections à coronavirus (anatomopathologie), Infections à coronavirus (diagnostic), Infections à coronavirus (virologie), Jeune adulte, Mâle, Médecine clinique (), Sujet âgé, Sujet âgé de 80 ans ou plus, Études cas-témoins.
MESH :
- anatomopathologie : Infections à coronavirus.
- diagnostic : Infections à coronavirus.
- isolement et purification : Coronavirus du syndrome respiratoire du Moyen-Orient.
- virologie : Infections à coronavirus.
Pascal (Inist)
- Adolescent, Adulte, Adulte d'âge moyen, Diagnostic différentiel, Enfant, Enfant d'âge préscolaire, Etude cas témoin, Femelle, Hospitalisation, Humains, Infection, Coronavirus, Homme, Jeune adulte, Mâle, Médecine clinique, Sujet âgé, Sujet âgé de 80 ans ou plus, Syndrome respiratoire du Moyen-Orient, Études cas-témoins.
Wicri :
- topic : Hospitalisation, Homme.

English descriptors

KwdEn :
- Adolescent, Adult, Aged, Aged, 80 and over, Case control study, Case-Control Studies, Child, Child, Preschool, Clinical Medicine (methods), Coronavirus, Coronavirus Infections (diagnosis), Coronavirus Infections (pathology), Coronavirus Infections (virology), Diagnosis, Differential, Female, Hospitalization, Human, Humans, Infection, Male, Middle Aged, Middle East Respiratory Syndrome Coronavirus (isolation & purification), Middle East respiratory syndrome, Young Adult.
MESH :
- diagnosis : Coronavirus Infections.
- isolation & purification : Middle East Respiratory Syndrome Coronavirus.
- methods : Clinical Medicine.
- pathology : Coronavirus Infections.
- virology : Coronavirus Infections.
- Adolescent, Adult, Aged, Aged, 80 and over, Case-Control Studies, Child, Child, Preschool, Diagnosis, Differential, Female, Humans, Male, Middle Aged, Young Adult.

Abstract

Background. There is a paucity of data regarding the differentiating characteristics of patients with laboratory-confirmed and those negative for Middle East respiratory syndrome coronavirus (MERS-CoV). Methods. This is a hospital-based case-control study comparing MERS-CoV-positive patients (cases) with MERS-CoV-negative controls. Results. A total of 17 case patients and 82 controls with a mean age of 60.7 years and 57 years, respectively (P = .553), were included. No statistical differences were observed in relation to sex, the presence of a fever or cough, and the presence of a single or multilobar infiltrate on chest radiography. The case patients were more likely to be overweight than the control group (mean body mass index, 32 vs 27.8; P = .035), to have diabetes mellitus (87% vs 47%; odds ratio [OR], 7.24; P = .015), and to have end-stage renal disease (33% vs 7%; OR, 7; P = .012). At the time of admission, tachypnea (27% vs 60%; OR, 0.24; P=.031) and respiratory distress (15% vs 51%; OR, 0.15; P = .012) were less frequent among case patients. MERS-CoV patients were more likely to have a normal white blood cell count than the control group (82% vs 52%; OR, 4.33; P = .029). Admission chest radiography with interstitial infiltrates was more frequent in case patients than in controls (67% vs 20%; OR, 8.13; P=.001). Case patients were more likely to be admitted to the intensive care unit (53% vs 20%; OR, 4.65; P = .025) and to have a high mortality rate (76% vs 15%; OR, 18.96; P < .001). Conclusions. Few clinical predictors could enhance the ability to predict which patients with pneumonia would have MERS-CoV. However, further prospective analysis and matched case-control studies may shed light on other predictors of infection.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7108071

Affiliations:

Arabie saoudite, États-Unis

Le document en format XML

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<front><div type="abstract" xml:lang="en">Background. There is a paucity of data regarding the differentiating characteristics of patients with laboratory-confirmed and those negative for Middle East respiratory syndrome coronavirus (MERS-CoV). Methods. This is a hospital-based case-control study comparing MERS-CoV-positive patients (cases) with MERS-CoV-negative controls. Results. A total of 17 case patients and 82 controls with a mean age of 60.7 years and 57 years, respectively (P = .553), were included. No statistical differences were observed in relation to sex, the presence of a fever or cough, and the presence of a single or multilobar infiltrate on chest radiography. The case patients were more likely to be overweight than the control group (mean body mass index, 32 vs 27.8; P = .035), to have diabetes mellitus (87% vs 47%; odds ratio [OR], 7.24; P = .015), and to have end-stage renal disease (33% vs 7%; OR, 7; P = .012). At the time of admission, tachypnea (27% vs 60%; OR, 0.24; P=.031) and respiratory distress (15% vs 51%; OR, 0.15; P = .012) were less frequent among case patients. MERS-CoV patients were more likely to have a normal white blood cell count than the control group (82% vs 52%; OR, 4.33; P = .029). Admission chest radiography with interstitial infiltrates was more frequent in case patients than in controls (67% vs 20%; OR, 8.13; P=.001). Case patients were more likely to be admitted to the intensive care unit (53% vs 20%; OR, 4.65; P = .025) and to have a high mortality rate (76% vs 15%; OR, 18.96; P < .001). Conclusions. Few clinical predictors could enhance the ability to predict which patients with pneumonia would have MERS-CoV. However, further prospective analysis and matched case-control studies may shed light on other predictors of infection.</div>
</front>
</TEI>
<affiliations><list><country><li>Arabie saoudite</li>
<li>États-Unis</li>
</country>
</list>
<tree><country name="Arabie saoudite"><noRegion><name sortKey="Al Tawfiq, Jaffar A" sort="Al Tawfiq, Jaffar A" uniqKey="Al Tawfiq J" first="Jaffar A." last="Al-Tawfiq">Jaffar A. Al-Tawfiq</name>
</noRegion>
<name sortKey="Ghandour, Jihad" sort="Ghandour, Jihad" uniqKey="Ghandour J" first="Jihad" last="Ghandour">Jihad Ghandour</name>
<name sortKey="Hinedi, Kareem" sort="Hinedi, Kareem" uniqKey="Hinedi K" first="Kareem" last="Hinedi">Kareem Hinedi</name>
<name sortKey="Khairalla, Hanan" sort="Khairalla, Hanan" uniqKey="Khairalla H" first="Hanan" last="Khairalla">Hanan Khairalla</name>
<name sortKey="Memish, Ziad A" sort="Memish, Ziad A" uniqKey="Memish Z" first="Ziad A." last="Memish">Ziad A. Memish</name>
<name sortKey="Memish, Ziad A" sort="Memish, Ziad A" uniqKey="Memish Z" first="Ziad A." last="Memish">Ziad A. Memish</name>
<name sortKey="Musleh, Samir" sort="Musleh, Samir" uniqKey="Musleh S" first="Samir" last="Musleh">Samir Musleh</name>
<name sortKey="Ujayli, Alaa" sort="Ujayli, Alaa" uniqKey="Ujayli A" first="Alaa" last="Ujayli">Alaa Ujayli</name>
</country>
<country name="États-Unis"><noRegion><name sortKey="Al Tawfiq, Jaffar A" sort="Al Tawfiq, Jaffar A" uniqKey="Al Tawfiq J" first="Jaffar A." last="Al-Tawfiq">Jaffar A. Al-Tawfiq</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

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Middle East Respiratory Syndrome Coronavirus: A Case-Control Study of Hospitalized Patients

Middle East Respiratory Syndrome Coronavirus: A Case-Control Study of Hospitalized Patients

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